Mouse Model

Our group is involved in the development a new animal model to study fetal to neonatal transition with mice pups bornmouse under hypoxic conditions, with an inspiratory oxygen fraction of 14%.  This model can have benefits compared to normal fetal to neonatal transition in terms of postnatal redox adaptation, inflammatory response and neurodevelopment. We study changes affecting different tissues including cerebral cortex and lung tissue as well as blood plasma. Physiological parameters of the mice pups are evaluated by blood gas measurements and alterations of their redox status and metabolism are studied on a molecular as well as genetic level.

mouse    mouse

Handling of mice pubs of one day of life is not easy, as they are very small and fragile. Hence, special equipment is required for the aquisition of physiological parameters. In the video you can see a mous pub with a throat clip sensor for measuring its pulse, breath rate, heart rate and oxgygen saturation.